Pediatric acute liver failure: Reexamining key clinical features, current management, and research prospects
Author(s) -
Ascher Bartlett Johanna M.,
Yanni George,
Kwon Yong,
Emamaullee Juliet
Publication year - 2022
Publication title -
liver transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.814
H-Index - 150
eISSN - 1527-6473
pISSN - 1527-6465
DOI - 10.1002/lt.26500
Subject(s) - medicine , intensive care medicine , liver transplantation , liver failure , immunosuppression , multidisciplinary approach , liver disease , intestinal failure , transplantation , surgery , parenteral nutrition , social science , sociology
Abstract This review aims to synthesize the most updated research, outcomes, and trends in the field of pediatric liver transplantation (LT), specifically focusing on children who have suffered from acute liver failure. Pediatric acute liver failure is a dynamic, life‐threatening condition that can either self‐resolve or lead to death. LT is a lifesaving intervention. With the introduction of technical variant grafts and recent immunosuppression modifications, overall patient survival, graft survival, and waitlist mortality have improved. Furthermore, recent advances in the knowledge of immunologic mediators of acute liver failure offer the possibility of more detailed understanding of the pathophysiology and new areas for research. Given the success of living donor LT for pediatric patients with acute liver failure, this option should continue to be actively considered as an alternative treatment option for patients who are listed for transplantation and are managed at a multidisciplinary tertiary care transplant center.
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