Open AccessRoles of skull base surgery and particle radiotherapy for orbital malignant tumors involving the skull base
Author(s) -
Teshima Masanori,
Shinomiya Hirotaka,
Kimura Hidehito,
Hashikawa Kazunobu,
Kiyota Naomi,
Miyawaki Daisuke,
Sasaki Ryohei,
Kohmura Eiji,
Nibu Kenichi
Publication year - 2021
Publication title -
laryngoscope investigative otolaryngology
Language(s) - English
Resource type - Journals
ISSN - 2378-8038
DOI - 10.1002/lio2.687
Subject(s) - medicine , skull , adenoid cystic carcinoma , radiation therapy , surgery , retrospective cohort study , chemoradiotherapy , basal cell , carcinoma , radiology
Purpose To investigate the oncological outcomes of orbital malignant tumors invading the skull base. Methods A retrospective analysis was conducted on 16 patients with orbital malignant tumors invading the skull base. Eleven patients were treated with skull base surgery, four patients were treated with particle therapies, and one patient was treated with chemoradiotherapy (CRT) as initial treatment. Results The most frequent histological type was adenoid cystic carcinoma in seven patients, followed by squamous cell carcinoma in two patients. Local recurrence occurred in two of the six surgically treated patients who did not receive postoperative radiotherapy (RT) or CRT. One of them was successfully salvaged by RT, and the other died of disease. With a median follow‐up of 24 months, the 2‐year overall, local control, and disease‐free survival rates of all patients were 82.5%, 87.5%, and 59%, respectively. Conclusions Patients with positive surgical margins were at risk of local recurrence. Postoperative RT should be considered for all surgically treated patients. Level of Evidence: 4.