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Objective  To evaluate the feasibility and outcomes of porcine submucosal allograft (Biodesign Sinonasal Repair Graft [Cook Medical, Bloomington, IN]) in oral cavity and oropharynx reconstruction after ablative surgery.    Methods  We conducted a prospective and retrospective review of patients who underwent Biodesign Sinonasal Repair Graft reconstruction for oral and oropharyngeal surgical defects at a single institution between 2018 and 2020. A total of 11 patients were included in the study. Data points included their perioperative medical and demographic data, immediate postoperative course, and follow‐up visits at 10 days and at 2 months. The clinicopathologic characteristics of their disease, postoperative esthetic, and functional outcomes were recorded and analyzed.    Results  Eleven procedures have been performed, and all patients received Biodesign reconstruction either immediately after ablation or after they failed a previous reconstruction. None of the patients had bone exposure. The subsites included oral tongue ( n  = 6), floor of the mouth ( n  = 3), buccal mucosa ( n  = 1), and soft palate ( n  = 1). In all cases, the operations and the postoperative course were uneventful. The mean defect size was 22 cm 2 . The median start of oral intake was at 2 days postoperatively. The Biodesign graft healed well in all patients with no total graft loss. There was one complication that required revision surgery due to obstruction of Wharton's duct by the Biodesign material.    Conclusions  Biodesign can be a viable option for small and medium‐sized oral and oropharyngeal defects in patients who are medically unfit or do not want to undergo a free flap surgery.    Level of Evidence  4.

Porcine small intestine graft for reconstruction of oral defects