Open AccessHead & neck melanoma: A 22‐year experience of recurrence following sentinel lymph node biopsy
Author(s) -
Echanique Kristen A.,
Ghazizadeh Shabnam,
Moon Andy,
Kwan Kera,
Pellionisz Peter A.,
Rünger Dennis,
Elashoff David,
St. John Maie
Publication year - 2021
Publication title -
laryngoscope investigative otolaryngology
Language(s) - English
Resource type - Journals
ISSN - 2378-8038
DOI - 10.1002/lio2.605
Subject(s) - medicine , sentinel lymph node , scalp , melanoma , stage (stratigraphy) , biopsy , univariate analysis , retrospective cohort study , multivariate analysis , proportional hazards model , primary tumor , head and neck cancer , lymph node , surgery , metastasis , oncology , cancer , breast cancer , cancer research , paleontology , biology
Abstract Objective To examine the clinicopathologic factors that contribute to regional and distant recurrence in intermediate to high risk head and neck melanoma patients after sentinel lymph node biopsy (SLNB). Methods This study is a retrospective review from an academic tertiary care center. Patients treated with SLNB for head and neck melanoma from 1997 to 2019 were reviewed and characterized by sentinel lymph node (SLN) status. Clinical variables were examined for the impact on regional and distant recurrence in SLNB‐negative patients using univariable and multivariable Cox regression analysis. Results One hundred and fifty four patients were included. Of note, 127 (82.5 %) were men, and the average age was 61.3 years. Median follow‐up was 68.6 weeks. Pathologic review of SLNs found 3.9% positive for metastatic melanoma; 96.1% were negative. Regional recurrence was significantly associated with tumor stage and age on multivariate analysis. A total of 4.5% of patients recurred in a previously labeled negative basin. Scalp subsite accounted for 30.5% of primary tumors and was more likely to yield a positive SLN on univariate analysis ( P = .023). Tumor stage and age were significantly associated with distant metastasis on multivariable analysis ( P = .026, P < .001 respectively). Conclusion We report a number of prognostic trends in head and neck melanoma. SLN positivity was found more often in patients with a primary tumor of the scalp. Regional recurrence was significantly associated with age and tumor stage, whereas distant recurrence was significantly associated with tumor staging and scalp subsite. Scalp subsite was associated with an increased risk for nodal metastasis and distant recurrence. Level of evidence 3.