Open AccessIntracochlear fibrosis and the foreign body response to cochlear implant biomaterials
Author(s) -
Foggia Megan J.,
Quevedo Rene Vielman,
Hansen Marlan R.
Publication year - 2019
Publication title -
laryngoscope investigative otolaryngology
Language(s) - English
Resource type - Journals
ISSN - 2378-8038
DOI - 10.1002/lio2.329
Subject(s) - cochlear implant , cochlea , cochlear implantation , foreign body , fibrosis , medicine , limiting , implant , audiology , surgery , pathology , engineering , mechanical engineering
Objective To report current knowledge on the topic of intracochlear fibrosis and the foreign body response following cochlear implantation (CI). Methods A literature search was performed in PubMed to identify peer‐reviewed articles. Search components included “cochlear implant,” “Foreign body response (FBR),” and “fibrosis.” Original studies and review articles relevant to the topic were included. Results Ninety peer‐reviewed articles describing the foreign body response or intracochlear fibrosis following CI were included. Conclusions Intracochlear fibrosis following CI represents a significant limiting factor for the success of CI users. Several strategies have been employed to mitigate the foreign body response within the cochlea including drug delivery systems and modifications in surgical technique and electrode design. A better understanding of the FBR has the potential to improve CI outcomes and the next generation of cochlear prostheses.