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Diagnostic Accuracy of 2‐Dimensional Shear Wave Elastography for the Staging of Liver Fibrosis: A Meta‐analysis
Author(s) -
Zhang Wei,
Zhu Ya,
Zhang Cuncheng,
Ran Haitao
Publication year - 2019
Publication title -
journal of ultrasound in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 91
eISSN - 1550-9613
pISSN - 0278-4297
DOI - 10.1002/jum.14760
Subject(s) - medicine , confidence interval , receiver operating characteristic , elastography , cirrhosis , fibrosis , liver fibrosis , meta analysis , nuclear medicine , radiology , gastroenterology , ultrasound
Objectives To evaluate the overall accuracy of 2‐dimensional shear wave elastography (SWE) for the staging of liver fibrosis. Methods Literature databases and conference abstracts were searched from 2000 to September 2017. Sensitivity, specificity, and other information were extracted from the included studies. Methodological quality was assessed with Quality Assessment of Diagnostic Accuracy Studies 2 tools. Data were synthesized by a bivariate hierarchical model. Results The summary sensitivity and specificity were 0.85 (95% confidence interval [CI], 0.80–0.89) and 0.79 (95% CI, 0.72–0.85) for fibrosis stage F≥2, 0.90 (95% CI, 0.87–0.93) and 0.85 (95% CI, 0.80–0.89) for F≥3, and 0.89 (95% CI, 0.84–0.93) and 0.92 (95% CI, 0.89–0.95) for F=4, respectively. The areas under the summary receiver operating characteristic curve for F≥2, F≥3, and F=4 was 0.81, 0.77, and 0.84. Conclusions Two‐dimensional SWE is a good noninvasive method for the diagnosis of substantial liver fibrosis and cirrhosis. Further studies are needed to assess severe fibrosis and to perform head‐to‐head comparisons of 2‐dimensional SWE and other imaging modalities for the evaluation of liver fibrosis.