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Methacrylate‐based chromatographic media
Author(s) -
Benes̆ Milan J.,
Horák Daniel,
Svec Frantisek
Publication year - 2005
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.200500186
Subject(s) - chromatography , methacrylate , chemistry , polymer , organic chemistry , monomer
Abstract This review summarizes the preparation and application of chromatographic separation media based on methacrylate monomers with a major focus on highly crosslinked macroporous beads prepared from 2‐hydroxyethyl methacrylate and glycidyl methacrylate, respectively. The effects of process variables such as composition of the polymerization mixture that includes monomers, porogenic solvents, and free radical initiator, suspension stabilizer, reaction temperature, and stirring are detailed for both classical and templated suspension polymerization. In addition, specific features of the preparation of monodisperse beads are also discussed. The performance of methacrylate‐based separation media is demonstrated on numerous separations in a variety of chromatographic modes.