Separation of racemic compounds on amylose and cellulose dimethylphenylcarbamate‐coated zirconia in HPLC

Zirconia particles are a very robust material and have received considerable attention as a stationary phase support for HPLC. Chromatographic performances of ADMPC‐ and CDMPC‐coated zirconia as chiral stationary phases (CSPs) were compared by measuring the chiral discrimination of a set of 14 racemic compounds on the two columns. On the whole CDMPC‐zirconia showed better chiral selectivity for the test compounds than ADMPC‐zirconia. The two CSPs show complementary chiral recognition capability for the types of racemates studied. Chiral selectivities of ADMPC‐ and CDMPC‐coated zirconia were also compared with those of ADMPC‐ and CDMPC‐coated silica. The zirconia CSPs exhibited comparable and sometimes better enantioselectivity than the corresponding silica CSPs.