Premium
Introducing fluorescence guided surgery into orthopedic oncology: A systematic review of candidate protein targets for Ewing sarcoma
Author(s) -
Bosma Sarah E,
Driel Pieter BAA,
Hogendoorn Pancras CW,
Dijkstra PD Sander,
Sier Cornelis FM
Publication year - 2018
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.25224
Subject(s) - medicine , sarcoma , chemotherapy , orthopedic surgery , soft tissue , radiation therapy , ewing's sarcoma , osteosarcoma , soft tissue sarcoma , surgery , radiology , pathology
Ewing sarcoma (ES), an aggressive bone and soft‐tissue tumor, is treated with chemotherapy, radiotherapy, and surgery. Intra‐operative distinction between healthy and tumorous tissue is of paramount importance but challenging, especially after chemotherapy and at complex anatomical locations. Near infrared (NIR) fluorescence‐guided surgery (FGS) is able to facilitate the determination of tumor boundaries intra‐operatively, improving complete resection and therefore survival. This review evaluates potential ES‐specific proteins from the literature as targets for NIR FGS.