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Selecting postoperative adjuvant systemic therapy for early stage breast cancer: A critical assessment of commercially available gene expression assays
Author(s) -
Hyams David M.,
Schuur Eric,
Angel Aristizabal Javier,
Bargallo Rocha Juan Enrique,
Cabello Cesar,
Elizalde Roberto,
GarcíaEstévez Laura,
Gomez Henry L.,
Katz Artur,
Nuñez De Pierro Aníbal
Publication year - 2017
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.24561
Subject(s) - medicine , breast cancer , stage (stratigraphy) , oncology , adjuvant chemotherapy , adjuvant therapy , adjuvant , systemic therapy , risk stratification , cancer , clinical decision making , intensive care medicine , paleontology , biology
Risk stratification of patients with early stage breast cancer may support adjuvant chemotherapy decision‐making. This review details the development and validation of six multi‐gene classifiers, each of which claims to provide useful prognostic and possibly predictive information for early stage breast cancer patients. A careful assessment is presented of each test's analytical validity, clinical validity, and clinical utility, as well as the quality of evidence supporting its use.