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BACKGROUND   Petroselinum crispum  (English parsley) is a common herb of the Apiaceae family that is cultivated throughout the world and is widely used as a seasoning condiment. Studies have shown its potential as a medicinal herb. In this study,  P. crispum  leaf and stem extracts were evaluated for their antioxidant properties, protection against  DNA  damage in normal  3T3‐L1  cells, and the inhibition of proliferation and migration of the  MCF ‐7 cells.    RESULTS  The dichloromethane extract of  P. crispum  exhibited the highest phenolic content (42.31 ± 0.50 mg  GAE  g −1 ) and ferric reducing ability (0.360 ± 0.009 mmol g −1 ) of the various extractions performed. The extract showed  DPPH  radical scavenging activity with an  IC 50   value of 3310.0 ± 80.5 µg  mL  −1 . Mouse fibroblasts ( 3T3‐L1 ) pre‐treated with 400 µg  mL  −1  of the extract showed 50.9% protection against  H 2 O 2  ‐induced  DNA  damage, suggesting its potential in cancer prevention. The extract (300 µg  mL  −1 ) inhibited  H 2 O 2  ‐induced  MCF ‐7 cell migration by 41% ± 4%. As cell migration is necessary for metastasis of cancer cells, inhibition of migration is an indication of protection against metastasis.    CONCLUSION   Petroselinum crispum  has health‐promoting properties with the potential to prevent oxidative stress‐related diseases and can be developed into functional food. © 2015 The Authors.  Journal of the Science of Food and Agriculture  published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

Petroselinum crispum has antioxidant properties, protects against DNA damage and inhibits proliferation and migration of cancer cells