Open AccessAtrial fibrillation and autonomic nervous system: A translational approach to guide therapeutic goals
Author(s) -
Rebecchi Marco,
Panattoni Germana,
Edoardo Bressi,
Ruvo Ermenegildo,
Sciarra Luigi,
Politano Alessandro,
Sgueglia Marianna,
Ricagni Chiara,
Verbena Sara,
Crescenzi Cinzia,
Sangiorgi Catia,
Borrelli Alessio,
De Luca Lucia,
Scarà Antonio,
Grieco Domenico,
Jacomelli Ilaria,
Martino Annamaria,
Calò Leonardo
Publication year - 2021
Publication title -
journal of arrhythmia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.463
H-Index - 21
eISSN - 1883-2148
pISSN - 1880-4276
DOI - 10.1002/joa3.12512
Subject(s) - medicine , renal sympathetic denervation , autonomic nervous system , atrial fibrillation , catheter ablation , obstructive sleep apnea , cardiology , ablation , denervation , sympathetic nervous system , therapeutic approach , neuroscience , blood pressure , heart rate , disease , resistant hypertension , biology
The autonomic nervous system (ANS) is known to play an important role in the genesis and maintenance of atrial fibrillation (AF). Biomolecular and genetic mechanisms, anatomical knowledges with recent diagnostic techniques acquisitions, both invasive and non‐invasive, have enabled greater therapeutic goals in patients affected by AF related to ANS imbalance. Catheter ablation of ganglionated plexi (GP) in the left and right atrium has been proposed in varied clinical conditions. Moreover interesting results arise from renal sympathetic denervation and vagal nerve stimulation. Despite all this, in the scenario of ANS modulation translational strategies we necessary must consider the treatment or correction of dynamic factors such as obesity, obstructive sleep apnea, lifestyle, food, and stress. Finally, new antiarrhythmic drugs, gene therapy and “ablatogenomic” could be represent exciting future therapeutic perspectives.