Open AccessMexiletine infusion challenge test for neonatal long QT syndrome with 2:1 atrioventricular block
Author(s) -
Okuwaki Hajime,
Kato Yoshiaki,
Lin Lisheng,
Nozaki Yoshihiro,
TakahashiIgari Miho,
Horigome Hitoshi
Publication year - 2019
Publication title -
journal of arrhythmia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.463
H-Index - 21
eISSN - 1883-2148
pISSN - 1880-4276
DOI - 10.1002/joa3.12209
Subject(s) - mexiletine , medicine , long qt syndrome , atrioventricular block , cardiology , anesthesia , qt interval
For applying a genotype‐based treatment in neonatal long QT syndrome (LQTS), early detection of the genotype becomes an important issue. We report a case of a neonate with LQTS type 3 that presented with 2:1 atrioventricular block and underwent a mexiletine infusion challenge test, and achieved shortening of the QTc and 1:1 atrioventricular conduction. The mexiletine infusion challenge test was helpful to make an early detection of the genotype of the LQTS and predicted the drug efficacy in a neonatal patient.