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Background  Brugada syndrome is an ion channelopathy that predisposes affected subjects to ventricular tachycardia/fibrillation ( VT / VF ), potentially leading to sudden cardiac death (SCD). T peak ‐T end  intervals, (T peak ‐T end )/ QT  ratio and T peak ‐T end  dispersion have been proposed for risk stratification, but their predictive values in Brugada syndrome have been challenged recently.    Methods  A systematic review and meta‐analysis was conducted to examine their values in predicting arrhythmic and mortality outcomes in Brugada Syndrome. PubMed and Embase databases were searched until 1 May 2018, identifying 29 and 57 studies.    Results  Nine studies involving 1740 subjects (mean age 45 years old, 80% male, mean follow‐up duration was 68 ± 27 months) were included. The mean T peak ‐T end  interval was 98.9 ms (95%  CI : 90.5‐107.2 ms) for patients with adverse events (ventricular arrhythmias or SCD) compared to 87.7 ms (95%  CI : 80.5‐94.9 ms) for those without such events, with a mean difference of 11.9 ms (95%  CI : 3.6‐20.2 ms,  P  = 0.005;  I  2  = 86%). Higher (T peak ‐T end )/ QT  ratios (mean difference = 0.019, 95%  CI : 0.003‐0.036,  P  = 0.024;  I  2  = 74%) and T peak ‐T end  dispersion (mean difference = 7.8 ms, 95%  CI : 2.1‐13.4 ms,  P  = 0.007;  I  2  = 80%) were observed for the event‐positive group.    Conclusion  T peak ‐T end  interval, (T peak ‐T end )/ QT  ratio and T peak ‐T end  dispersion were higher in high‐risk than low‐risk Brugada subjects, and thus offer incremental value for risk stratification.

journal of arrhythmia

T peak ‐T end , T peak ‐T end / QT  ratio and T peak ‐T end  dispersion for risk stratification in Brugada Syndrome: A systematic review and meta‐analysis