Open AccessT peak ‐T end , T peak ‐T end / QT ratio and T peak ‐T end dispersion for risk stratification in Brugada Syndrome: A systematic review and meta‐analysis
Author(s) -
Tse Gary,
Gong Mengqi,
Li Christien Ka Hou,
Leung Keith Sai Kit,
Georgopoulos Stamatis,
Bazoukis George,
Letsas Konstantinos P.,
Sawant Abhishek C.,
Mugnai Giacomo,
Wong Martin C.S.,
Yan Gan Xin,
Brugada Pedro,
Chierchia GianBattista,
Asmundis Carlo,
Baranchuk Adrian,
Liu Tong
Publication year - 2018
Publication title -
journal of arrhythmia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.463
H-Index - 21
eISSN - 1883-2148
pISSN - 1880-4276
DOI - 10.1002/joa3.12118
Subject(s) - medicine , brugada syndrome , cardiology , ventricular fibrillation , ventricular tachycardia
Background Brugada syndrome is an ion channelopathy that predisposes affected subjects to ventricular tachycardia/fibrillation ( VT / VF ), potentially leading to sudden cardiac death (SCD). T peak ‐T end intervals, (T peak ‐T end )/ QT ratio and T peak ‐T end dispersion have been proposed for risk stratification, but their predictive values in Brugada syndrome have been challenged recently. Methods A systematic review and meta‐analysis was conducted to examine their values in predicting arrhythmic and mortality outcomes in Brugada Syndrome. PubMed and Embase databases were searched until 1 May 2018, identifying 29 and 57 studies. Results Nine studies involving 1740 subjects (mean age 45 years old, 80% male, mean follow‐up duration was 68 ± 27 months) were included. The mean T peak ‐T end interval was 98.9 ms (95% CI : 90.5‐107.2 ms) for patients with adverse events (ventricular arrhythmias or SCD) compared to 87.7 ms (95% CI : 80.5‐94.9 ms) for those without such events, with a mean difference of 11.9 ms (95% CI : 3.6‐20.2 ms, P = 0.005; I 2 = 86%). Higher (T peak ‐T end )/ QT ratios (mean difference = 0.019, 95% CI : 0.003‐0.036, P = 0.024; I 2 = 74%) and T peak ‐T end dispersion (mean difference = 7.8 ms, 95% CI : 2.1‐13.4 ms, P = 0.007; I 2 = 80%) were observed for the event‐positive group. Conclusion T peak ‐T end interval, (T peak ‐T end )/ QT ratio and T peak ‐T end dispersion were higher in high‐risk than low‐risk Brugada subjects, and thus offer incremental value for risk stratification.