Open AccessBrugada syndrome and sinus node dysfunction
Author(s) -
Hayashi Hidemori,
Sumiyoshi Masataka,
Nakazato Yuji,
Daida Hiroyuki
Publication year - 2018
Publication title -
journal of arrhythmia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.463
H-Index - 21
eISSN - 1883-2148
pISSN - 1880-4276
DOI - 10.1002/joa3.12046
Subject(s) - medicine , brugada syndrome , cardiology , ventricle , atrial fibrillation , concomitant
Brugada syndrome (BrS) is a well‐known catastrophic disease first reported in 1992 by the Brugada brothers. Ventricular fibrillation ( VF ) is an essential arrhythmia in BrS. An association between BrS and atrial tachyarrhythmias is not uncommon. However, sinus node dysfunction ( SND ) associated with BrS has not been well discussed. In this review, we focus on the association between BrS and SND . Based on previous reports describing clinical, epidemiological, and genetic evidence, SND is not a rare concomitant disorder in BrS. BrS may be a multiple conduction or arrhythmogenic disorder including not only the His‐Purkinje system and right ventricle, but also the sinus node and atrium, derived from ion channel mutations.