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Background  Whether nonsustained ventricular tachycardia ( NSVT ) is a marker of increased risk of sustained ventricular tachyarrhythmias ( VTA s) remains to be established in patients receiving cardiac resynchronization therapy with a defibrillator ( CRT ‐D) for primary prevention.    Methods  Among the follow‐up data of the Japan cardiac device treatment registry ( JCDTR ) with an implantation date between January 2011 and August 2015, information regarding a history of  NSVT  before the  CRT ‐D implantation for primary prevention had been registered in 269 patients. Outcomes were compared between two groups with and without  NSVT :  NSVT  group (n = 179) and No  NSVT  group (n = 90).    Results  There was no significant difference with regard to age, gender, and  NYHA  class between the two groups. Left ventricular ejection fraction ( LVEF ) was 25.6% in the  NSVT  group and 28.0% in the No  NSVT  group ( P  = .046). The rate of appropriate therapy at 24 months was 26.0% and 18.4% in the  NSVT  and No  NSVT  groups ( P  = .22), respectively. Survival free from heart failure death was reduced in the  NSVT  group, as compared with the No  NSVT  group, with the rate of 90.2% vs 97.2% at 24 months ( P  = .030). A multivariate analysis identified a history of  NSVT , anemia, and no use of angiotensin‐converting enzyme inhibitor ( ACEI ) or angiotensin‐receptor blocker ( ARB ) as predictors of heart failure death.    Conclusions   NSVT  appears to be a surrogate marker of severe heart failure rather than a substrate for subsequent sustained  VTA s in patients with  CRT ‐D for primary prevention.

journal of arrhythmia

Prognostic significance of nonsustained ventricular tachycardia in patients receiving cardiac resynchronization therapy for primary prevention: Analysis of the Japan cardiac device treatment registry database