Premium
The synthesis of 14 C‐diethylamine and lysergic acid diethylamide
Author(s) -
Barnes R. D.
Publication year - 1974
Publication title -
journal of labelled compounds
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0022-2135
DOI - 10.1002/jlcr.2590100204
Subject(s) - diethylamine , chemistry , ethylamine , lysergic acid diethylamide , lysergic acid , aluminum hydride , lithium aluminium hydride , triethylamine , amide , organic chemistry , medicinal chemistry , catalysis , receptor , biochemistry , serotonin , methoxide
The preparation of lysergic acid [ 14 C 1 ]‐diethylamide is described. [ 14 C 1 ]‐Diethylamine was synthesised in three steps; sodium [ 14 C 1 ]‐acetate was treated with thionyl chloride giving [ 14 C 1 ]‐acetyl chloride which was reacted with ethylamine to give N‐ethyl‐[ 14 C 1 ]‐acetamide. Reduction of this amide with lithium aluminium hydride gave [ 14 C 1 ]‐diethylamine which on treatment with a lysergic acid‐imidazole complex gave the required product.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom