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Synthesis of [ 11 C]S12968 and [ 11 C]S12967 for imaging the cardiac calcium channels using pet
Author(s) -
Dollé F.,
Valette H.,
Hinnen F.,
Demphel S.,
Bramoullé Y.,
Péglion J.L.,
Crouzel C.
Publication year - 2001
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.25804401142
Subject(s) - chemistry , trifluoromethanesulfonate , myocardial imaging , calcium , radiochemistry , pet imaging , carbon 14 , calcium imaging , positron emission tomography , nuclear chemistry , nuclear medicine , organic chemistry , catalysis , nuclear physics , physics , medicine
The dihydropyridines S12968 and S12967, two potent and selective calcium channel antagonists, have been labelled with carbon‐11 using no‐carrier‐added [ 11 C]methyl triflate and the dedicated, enantiomerically pure carboxylic acid precursor at 100°C for 1 minute. Based on preliminary PET experiments, only S12968 appears to be suitable for myocardial PET imaging.