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Synthesis of mycophenolate mofetil‐[ 14 C], RS‐61443‐ 14 C
Author(s) -
Huang Glenn T.,
Parnes Howard
Publication year - 1995
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580360508
Subject(s) - mycophenolate , chemistry , mycophenolic acid , yield (engineering) , chemical synthesis , medicinal chemistry , nuclear chemistry , radiochemistry , stereochemistry , in vitro , transplantation , biochemistry , medicine , materials science , metallurgy
Synthesis of the potent immunosuppressive agent, mycophenolate mofetil ( 1 ) labelled with carbon‐14 is described. Methoxyethoxymethyl (MEM) protected mycophenolate norbromide ( 9 ) was prepared from unlabelled mycophenolic acid ( 2 ) using a modified Hunsdiecker reaction. A three step synthesis furnished the title compound, having a specific activity of 53.8 mCi/mmol, in 49.5% overall yield from K 14 CN.
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