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Synthesis of four tritium‐labelled aminowarfarin methyl ketal regioisomers
Author(s) -
Obach R. Scott,
Kaminsky Laurence S.
Publication year - 1992
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580311005
Subject(s) - chemistry , tritium , structural isomer , organic chemistry , stereochemistry , combinatorial chemistry , nuclear physics , physics
6‐Bromo‐4′‐nitro‐, 4′‐bromo‐6‐nitro‐, 4′‐bromo‐7‐nitro‐ and 4′‐bromo‐8‐nitrowarfarin methyl ketals were prepared and together subjected to catalytic tritiation over palladium on charcoal to produce tritium‐labelled aminowarfarin methyl ketals. The four regioisomers were separated by thin‐layer chromatography to yield pure compounds of high (24.9–29.8 Ci/mmol) specific activity.