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Isotopically labelled adenosine triphosphate analogues: Synthesis of [6‐ 15 N]‐ adenylyl imidodiphosphate and [6‐ 15 N]‐adenylyl methylenediphosphonate
Author(s) -
Sarfati S. R.,
Pochet S.
Publication year - 1991
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580291209
Subject(s) - chemistry , inosine , adenosine , yield (engineering) , adenosine triphosphate , biochemistry , materials science , metallurgy
We report the synthesis of [6‐ 15 N]‐labeled‐AMP following a novel route from adenosine with an overall yield (12%) better than with a previously described procedure from inosine (6%). The two analogues of [6‐ 15 N]‐adenosine triphosphate, adenylyl imidodiphosphate (AMP‐PNP) and adenylyl methylenediphosphonate (AMP‐PCP), were prepared from labeled AMP.