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Radiosynthesis of [ 11 C]‐N‐methylacyclovir
Author(s) -
Wilson Alan A.,
Conti Peter S.,
Dannals Robert F.,
Ravert Hayden T.,
Wagner Henry N.
Publication year - 1991
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580290705
Subject(s) - radiosynthesis , chemistry , yield (engineering) , guanine , positron emission tomography , radiochemistry , stereochemistry , nuclear medicine , biochemistry , physics , medicine , nucleotide , gene , thermodynamics
A selective and potent analogue of the anti‐herpes agent acyclovir has been labelled with 11 C in good yield and at high specific activities. 1‐[ 11 C]‐Methyl‐9‐(2‐hydroxyethoxy)methyl)guanine may be useful for detecting HSV encephalitis using positron emission tomography.
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