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Rapid synthesis of radiolabeled phenylethanolamine
Author(s) -
Hussain Munir A.,
Chaney James E.,
Jay Michael,
Digenis George A.
Publication year - 1990
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580280402
Subject(s) - chemistry , cyanohydrin , anhydrous , benzaldehyde , chemical synthesis , organic chemistry , solvent , biochemistry , catalysis , in vitro
A method for the rapid synthesis of [ 14 C]‐phenylethanolamine (PEOH) amenable to the preparation of [ 11 C]‐PEOH was developed under anhydrous conditions. Reaction of benzaldehyde with [ 14 C]‐NaCN in the presence of crown ethers in THF yielded [ 14 C]‐cyanohydrin which was reduced to [ 14 C]‐PEOH with borane in the same solvent. The overall chemical and radiochemical yields were 33%.
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