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Synthesis and preliminary evaluation of L‐6‐[ 123 I]Iododopa as a potential spect brain imaging agent
Author(s) -
Adam Michael J.,
Ponce Yolanda Zea,
Berry Joffre M.,
Hoy Kevin
Publication year - 1990
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580280205
Subject(s) - chemistry , radiochemistry , specific activity , yield (engineering) , bromine , striatum , spect imaging , nuclear chemistry , nuclear medicine , biochemistry , medicine , organic chemistry , materials science , dopamine , metallurgy , enzyme
L‐6‐[ 123 I]Iododopa was synthesized by the exchange of 123 I for bromine on L‐6‐bromodopa in buffer(pH 4) for 35 minutes at 97°C. The synthesis was complete in approximately 1 hour with a radiochemical yield of 50%, a specific activity of 65 Ci/mmol and a radiochemical purity of ≥95%. A non radioactive standard of L‐6‐iododopa was synthesized by the iododemercuration of a mercury‐dopa derivative using I 2 in chloroform. It was shown that L‐6‐[ 123 I]iododopa accumulated in the rat striatum with striatum:whole brain ratio of 1.36 at 1 hour and 1.11 at 2 hours.