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Synthesis of 3‐quinuclidinol‐ 18 O, benzilic‐d 5 acid, and 3‐quinuclidinyl‐ 18 O benzilate‐d 5
Author(s) -
Sniegoski Lorna T.,
Byrd Gary D.,
White V Edward
Publication year - 1989
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580270902
Subject(s) - chemistry , quinuclidinyl benzilate , mass spectrum , isotope dilution , kinetic isotope effect , mass spectrometry , medicinal chemistry , ion , deuterium , organic chemistry , chromatography , biochemistry , physics , receptor , acetylcholine receptor , quantum mechanics
Isotopically labeled analogs of 3‐quinuclidinol (Q), benzilic acid (BA), and 3‐quinuclidinyl benzilate (BZ), for use as internal standards for isotope dilution measurements and the labeled intermediates 3‐quinuclidinone and methyl benzilate used in their production, were synthesized. The isotopic purities of the 1‐azabicyclo[2.2.2]octan‐3‐ 18 O‐ol, α‐hydroxy‐a‐phenyl‐d 5 ‐benzeneacetic acid, and 3‐quinuclidinyl‐ 18 O benzilate‐d 5 were determined and the electron impact ionization mass spectrum was obtained for each.