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Syntheses of 14 C‐labelled prizidilol dihydrochloride
Author(s) -
Saunders D,
Warrington B H
Publication year - 1985
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580220902
Subject(s) - chemistry , yield (engineering) , pyridazine , radiochemistry , stereochemistry , medicinal chemistry , metallurgy , materials science
Two syntheses of radiolabelled prizidilol dihydrochloride (DL)3‐[2‐(3‐t‐butylamino ‐2‐hydroxypropoxy)phenyl]‐6‐hydrazino‐pyridazine dihydrochloride) are described. 1. A ten stage synthesis (Scheme 1) which gave [3,6‐ 14 C 2 ] prizidilol dihydrochloride (10) in an overall yield of 0.91%. 2. A later, alternative procedure (scheme 2) leading to [4,5‐ 14 C 2 ] prizidilol dihydrochloride (16) with an overall radiochemical yield of 8%.
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