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Comparison of tritiation efficiency using 3 H 3 + and 3 H 2 + ion beams
Author(s) -
Richardson B. C.,
Kam ChihMin,
Powers J. C.,
Moran T. F.
Publication year - 1984
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580211006
Subject(s) - chemistry , leupeptin , ion , tritium , aldehyde , magnet , radiochemistry , analytical chemistry (journal) , nuclear physics , chromatography , catalysis , organic chemistry , physics , protease , enzyme , quantum mechanics
A new apparatus was constructed to tritiate biological molecules using mass analysed tritium ion beams. The magnetic sector of this device was constructed of high field Sm‐Co permanent magnets. Mass analyzed ions of desired kinetic energy were impacted on an involatile solid and 3 H exchanged for H. The 3 H 2 + ions were found to be more reactive than 3 H 2 + ions. The sensitive peptide aldehyde leupeptin was utilized to test the efficacy of mass analyzed ion beam tritiation and leupeptin was not decomposed by this process.