Premium
[N‐methyl‐ 11 C]‐scopolamine: Synthesis and distribution in rat brain
Author(s) -
Vora Manhar M.,
Finn Ronald D.,
Boothe Thomas E.,
Liskwosky David R.,
Potter Lincoln T.
Publication year - 1983
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580201103
Subject(s) - chemistry , muscarinic acetylcholine receptor , muscarinic antagonist , sodium cyanoborohydride , muscarine , scopolamine , high performance liquid chromatography , antagonist , population , in vivo , distribution (mathematics) , chromatography , receptor , pharmacology , medicinal chemistry , biochemistry , medicine , mathematical analysis , demography , microbiology and biotechnology , mathematics , sociology , biology
The muscarinic antagonist [N‐methyl‐ 11 C]‐scopolamine was synthesized by reductive methylation of norscopolamine with H 11 CHO and sodium cyanoborohydride, and then purified using preparative high performance liquid chromatography (HPLC). Preliminary in vivo studies in rat suggest the distribution of this compound to parallel with the muscarine receptor population in the brain.