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Tritium labelling of benzamide drugs
Author(s) -
PriBar Ilan,
Buchman Ouri
Publication year - 1983
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580201004
Subject(s) - benzamide , chemistry , sulpiride , metoclopramide , labelling , tritium , radiochemistry , chromatography , medicinal chemistry , antagonist , biochemistry , medicine , receptor , physics , vomiting , nuclear physics
Methods for tritiation of sulpiride, sultopride and metoclopramide were developed and optimized. 3 H‐sulpiride (7.1 Ci/mmol), 3 H‐sultopride (2.1 Ci/mmol) and 3 H‐metoclopramide (18.0 Ci/mmol) were obtained by hydrodebromination of the related bromo derivatives. The bromo derivatives were prepared, in turn, by appropriate procedures specified for each case.