2 H‐labelled 3α‐hydroxy‐5α‐pregnane‐11,20‐dione and 3α,21‐dihydroxy‐5α‐pregnane‐11,20‐dione 21‐acetate

3α‐Hydroxy‐5α‐pregnane‐11,20‐dione‐2,2,3,4,4‐ 2 H 5 of 78% isotopic purity was prepared from 3α‐hydroxy‐5α‐pregnane‐11,20‐dione. The major impurity (10%) was 3α‐hydroxy‐5α‐pregnane‐11,20‐dione‐2,2,4,4‐ 2 H 4 . 3α,21‐Dihydroxy‐5α‐pregnane‐11,20‐dione‐2,2,3,4,4‐ 2 H 5 21‐acetate of 76% isotopic purity was prepared by reaction of the deuterated 3α‐hydroxy compound with lead tetraacetate. The major impurity (10%) was 3α,21‐dihydroxy‐5α‐pregnane‐11,20‐dione‐2,2,4,4‐ 2 H 4 .