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2 H‐labelled 3α‐hydroxy‐5α‐pregnane‐11,20‐dione and 3α,21‐dihydroxy‐5α‐pregnane‐11,20‐dione 21‐acetate
Author(s) -
Vine J.,
Treloar K.
Publication year - 1982
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580190414
Subject(s) - pregnane , chemistry , pregnane x receptor , deuterium , medicinal chemistry , impurity , stereochemistry , organic chemistry , biochemistry , quantum mechanics , gene , physics , nuclear receptor , transcription factor
3α‐Hydroxy‐5α‐pregnane‐11,20‐dione‐2,2,3,4,4‐ 2 H 5 of 78% isotopic purity was prepared from 3α‐hydroxy‐5α‐pregnane‐11,20‐dione. The major impurity (10%) was 3α‐hydroxy‐5α‐pregnane‐11,20‐dione‐2,2,4,4‐ 2 H 4 . 3α,21‐Dihydroxy‐5α‐pregnane‐11,20‐dione‐2,2,3,4,4‐ 2 H 5 21‐acetate of 76% isotopic purity was prepared by reaction of the deuterated 3α‐hydroxy compound with lead tetraacetate. The major impurity (10%) was 3α,21‐dihydroxy‐5α‐pregnane‐11,20‐dione‐2,2,4,4‐ 2 H 4 .