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Synthesis of 14 C‐labeled 10,11‐epoxyfarnesyl diazoacetate, a potential photoaffinity labeling reagent for insect juvenile hormone binding proteins
Author(s) -
Krafft Grant A.,
Reich Marvin F.,
Katzenellenbogen John A.
Publication year - 1982
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580190413
Subject(s) - chemistry , photoaffinity labeling , juvenile hormone , ethyl diazoacetate , reagent , glyoxylic acid , stereochemistry , biochemistry , hormone , combinatorial chemistry , organic chemistry , binding site , catalysis , cyclopropanation
The synthesis of [ 14 C]‐10,11‐Epoxy‐(2 E ,6E)‐farnesyl diazoacetate in one vessel, starting from [ 14 C]‐glyoxylic acid, is described. This compound is useful as a potential photoaffinity labeling agent for juvenile hormone binding sites.