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Synthesis of N,N‐[methyl‐ 14 C]‐dimethylhydrazine of high specific activity
Author(s) -
Cazer Frederick D.,
Kausar Abdul R.,
Kumar Kultar S.,
Inbasekaran Muthiah N.,
Witiak Donald T.
Publication year - 1982
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580190412
Subject(s) - chemistry , hydrazone , dimethylhydrazine , methyl iodide , hydrolysis , acetophenone , hydrochloride , yield (engineering) , ammonia , carbon 14 , medicinal chemistry , iodide , specific activity , organic chemistry , nuclear chemistry , catalysis , enzyme , medicine , materials science , colorectal cancer , cancer , metallurgy , physics , quantum mechanics
N,N‐[Methyl‐ 14 C]‐Dimethylhydrazine hydrochloride () having a specific activity of 115 mCi/mmol, was synthesized in two steps. Dimethylation of acetophenone hydrazone with 14 C‐methyl iodide (specific activity = 58 mCi/mmol) in the presence of potassium in liquid ammonia followed by acid catalyzed hydrolysis of the hydrazone afforded in a yield of 60.0% (>97% radiochemical purity).
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