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Synthesis of tritium‐abeled fosfomycin
Author(s) -
Mertel Holly E.,
Meriwether Henry T.
Publication year - 1982
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580190313
Subject(s) - tritium , chemistry , fosfomycin , tritium illumination , radiochemistry , amine gas treating , nuclear chemistry , organic chemistry , antibiotics , biochemistry , nuclear physics , physics
Tritium gas was used as a labeling agent for the preparation of [1,2 −3 H]fosfomycin. Introduction of tritium into a precursor, the synthesis including resolution of the intermediate racemic 1,2‐epoxypropylphosphonic acid, and preparation of both amine and calcium salts of the labeled antibiotic are described.