Synthesis of tritium‐abeled fosfomycin

Tritium gas was used as a labeling agent for the preparation of [1,2 −3 H]fosfomycin. Introduction of tritium into a precursor, the synthesis including resolution of the intermediate racemic 1,2‐epoxypropylphosphonic acid, and preparation of both amine and calcium salts of the labeled antibiotic are described.