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18 O labeled nucleosides. 1. A general method for the synthesis of specifically labeled pyrimidine deoxyribosides
Author(s) -
Schram Karl H.,
Ratcliff Steven,
Neenan John
Publication year - 1982
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580190312
Subject(s) - chemistry , pyrimidine , thymidine , base (topology) , mass spectrometry , sugar , stereochemistry , combinatorial chemistry , chromatography , dna , organic chemistry , biochemistry , mathematical analysis , mathematics
A facile method for the preparation of 18 O labeled pyrimidine deoxyribosides is described. The method provides a means of selectively labeling the base, sugar or both the base and sugar moieties with high levels of 18 O. Thymidine is used as a model to illustrate the method. The site and level of label was established using mass spectrometry.