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9α, 11α ‐tritiummarkierte östradiolderivate
Author(s) -
Römer Johannes,
Schwarz Sigfrid,
Weber Gisela
Publication year - 1981
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580180906
Subject(s) - chemistry , tritium , radiochemistry , tritium illumination , specific activity , combinatorial chemistry , organic chemistry , nuclear physics , enzyme , physics
In present work the syntheses of derivatives of 9α, 11α tritium labelled estradiols are described. Estron, estradiol, 17α‐ethynylestradiol and its 3‐isopropylsulfonyl ester were synthesized with high specific activity. Comparing the specific activities of all products it was obvious that tritium is exchanged in considerable amount in the strongly alkaline medium of ethynylation step. We believe that this exchange is attributed to tritium in benzylic positions.
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