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Syntheses of two kinds of 14 C‐labelled 4‐(N‐benzoyl‐L‐tyrosyl) aminobenzoic acids
Author(s) -
Yoshino H.,
Tsuchiya Y.,
Sato T.,
Kinoshita K.,
Uchiyama M.
Publication year - 1978
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580150103
Subject(s) - chemistry , aminobenzoic acid , p aminobenzoic acid , carbon 14 , pancreatic function , organic chemistry , medicinal chemistry , biochemistry , pancreas , physics , quantum mechanics
4‐(N‐benzoyl‐L‐tyrosyl) aminobenzoic acid, a diagnostic agent for a pancreatic exocrine function test, was labelled with carbon‐14. The synthetic procedure of 4‐(N‐benzoyl‐L‐tyrosyl)‐aminobenzoic[carboxy‐ 14 C] acid (I) and 4‐(N‐benzoyl [carbonyl‐ 14 C]‐L‐tyrosyl)aminobenzoic acid (II) is described. The overall radiochemical yields for (I) and (II) were 75.4% and 22.5%, respectively.