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Synthesis of tritium‐labelled 7α‐hydroxy and 7β‐hydroxy dehydroepiandrosterone
Author(s) -
Couch R. A. F.,
Skinner S. J. M.
Publication year - 1978
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580140102
Subject(s) - chemistry , dehydroepiandrosterone , tritium , epimer , allylic rearrangement , substrate (aquarium) , radiochemistry , stereochemistry , organic chemistry , biochemistry , androgen , hormone , catalysis , physics , nuclear physics , oceanography , geology
Abstract Tritium labelled 7α‐hydroxy and 7β‐hydroxy dehydroepiandrosterone were synthesised by the allylic acyloxylation of [1,2‐ 3 H(n)] dehydroepiandrosterone‐3β‐acetate with t‐butylperbenzoate. The 7α epimer was of comparable specific activity to the substrate.