Premium
Synthesis of tritium‐labelled 7α‐hydroxy and 7β‐hydroxy dehydroepiandrosterone
Author(s) -
Couch R. A. F.,
Skinner S. J. M.
Publication year - 1978
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580140102
Subject(s) - chemistry , dehydroepiandrosterone , tritium , epimer , allylic rearrangement , substrate (aquarium) , radiochemistry , stereochemistry , organic chemistry , biochemistry , androgen , hormone , catalysis , physics , nuclear physics , oceanography , geology
Tritium labelled 7α‐hydroxy and 7β‐hydroxy dehydroepiandrosterone were synthesised by the allylic acyloxylation of [1,2‐ 3 H(n)] dehydroepiandrosterone‐3β‐acetate with t‐butylperbenzoate. The 7α epimer was of comparable specific activity to the substrate.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom