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Tritium labelling of pharmaceuticals by metal‐catalysed exchange methods
Author(s) -
Hesk D.,
Lavey C. F.,
McNamara P.
Publication year - 2010
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.1800
Subject(s) - chemistry , tritium , labelling , tritium illumination , homogeneous , metal , catalysis , radiochemistry , tritiated water , combinatorial chemistry , nuclear chemistry , organic chemistry , nuclear physics , biochemistry , physics , thermodynamics
Metal‐catalysed exchange with tritiated water and tritium gas has been extensively used to prepare a wide range of tritium‐labelled compounds in support of pharmaceutical research. Examples of the utility of both heterogeneous and homogeneous metal catalysts to label a very broad range of structures will be discussed in this review. Copyright © 2010 John Wiley & Sons, Ltd.
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