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Synthese von (+)‐Coriolin B aus (+)‐Präcoriolin
Author(s) -
Weinges Klaus,
Braun Ralf
Publication year - 1994
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.199419940117
Subject(s) - chemistry , methylene , stereochemistry , medicinal chemistry
Synthesis of (+)‐Coriolin B from (+)‐Precoriolin Enantiomerically pure (3a S ,3b R ,4 R ,6a S ,7 S )‐(+)‐3,3a,4,5,6,6a,7‐Octahydro‐4,7‐dihydroxy‐3a,5,5‐trimethyl‐3‐methylene 2 H ‐cyclopenta[ a ]pentalen‐2‐one [(+)‐precoriolin] ( 4 ), produced from ( S )‐(+)‐carvone ( 3 ), is converted via the epoxides 5 and 7 into (+)‐coriolin B ( 2 ).