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Zur Konformation und Konfiguration der Cholecalciferol‐Isoxazolin‐Addukte
Author(s) -
Reischl Wolfgang,
Hofer Otmar,
Weissensteiner Walter
Publication year - 1993
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.199319930197
Subject(s) - cholecalciferol , chemistry , adduct , stereochemistry , nitrile , vitamin , organic chemistry , biochemistry
On the Conformation and Configuration of the Cholecalciferol‐Isoxazoline Adducts The conformation and configuration of compounds 1 – 4 , generated by 1,3‐dipolar addition of nitrile oxides to the exomethylene group of (5 Z )‐ and (5 E )‐vitamin D 3 has been assigned. A combination of force‐field calculations, LIS measurements, LIS simulations and CD spectroscopy has been used. In addition, the assignment has been verified by chemical correlation of 1 and 3 to 5 as well as of 2 and 4 to 6 .
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