Bausteine von Oligosacchariden, CVI. Darstellung synthetischer Antigene von LD ‐Heptose‐haltigen Trisacchariden der Core‐Region von Lipopolysacchariden durch Copolymerisation mit Acrylamid

Building Units of Oligosaccharides, CVI. – Preparation of Synthetic Antigens Composed of LD ‐Heptose‐Containing Trisaccharides of the Core Region of Lipopolysaccharides by Copolymerization with Acrylamide The allyl glycosides of the trisaccharide L ‐α‐ D ‐Hep‐(1→3)‐α‐ D ‐Hep‐(1→5)‐Kdo in the α form 3 and β form 6 and furthermore of L ‐α‐ D ‐Hep‐(1→7)‐ L ‐α‐ D ‐Hep‐(1→3)‐ L ‐α‐ D ‐Hep in the α form 20 were synthesized. The allyl glycosides were coupled with a cysteamin spacer in a radical‐addition reaction followed by an acylation with acryloyl chloride. The products could be copolymerized with acrylamide to afford the polymers 21 , 22 and 23 with the trisaccharide structure as an immunological determinant.