Premium
3a,8b‐Dihydro‐7‐methoxy‐8b‐(trifluoromethyl)‐2 H ‐indeno[1,2‐ b ]furan‐2,4(3 H )‐dione
Author(s) -
Ukerun Sylvester Ohwevwo
Publication year - 1989
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.198919890213
Subject(s) - chemistry , trifluoromethyl , furan , hydrolysis , ketone , lactone , stereochemistry , medicinal chemistry , organic chemistry , alkyl
3‐(Methoxycarbonyl)‐4‐(3‐methoxyphenyl)‐4‐(trifluoromethyl)‐4‐butanolide ( 4 ) was synthesised from 3‐methoxyphenyl trifluoromethyl ketone ( 1 ). Hydrolysis of the lactone ester 4 , followed by treatment with polyphosphoric acid, led to an intermediate lactone acid 3 , which on heating with PCl 5 gave the indeno‐[1,2‐ b ]furandione 5 .
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom