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Synthesis and spectral properties of 5‐methylthio‐4 H ‐1‐( p ‐substituted‐phenyl)‐3a‐( p ‐substituted‐phenyl)‐9‐[( m ‐; and p ‐substituted)‐phenoxy]‐3a,4‐dihydro[1,2,4]oxadiazolo[4,5‐ a ][1,5]benzodiazepines
Author(s) -
Cortés Eduardo CortÉS,
Cruz Elide HernÁNdez,
Mellado Olivia GarcÍA
Publication year - 1999
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570360224
Subject(s) - chemistry , benzonitrile , triethylamine , cycloaddition , spectral properties , proton nmr , medicinal chemistry , nitrile , stereochemistry , benzodiazepine , chloride , carbon 13 nmr , organic chemistry , catalysis , computational chemistry , biochemistry , receptor
Abstract The preparation of eight novel substituted [1,2,4]oxadiazolo[4,5‐ a ][1,5]benzodiazepines which have potentially useful pharmacological properties; by 1,3‐cycloaddition of benzonitrile oxides, generated in situ from benzohydroxamoyl chloride and triethylamine, to 1,5‐benzodiazepine derivatives is described. The structure of all products was corroborated by ir, 1 H‐nmr, 13 C‐nmr and ms.