Synthesis and spectral properties of 5‐methylthio‐4 H ‐1‐( p ‐substituted‐phenyl)‐3a‐( p ‐substituted‐phenyl)‐9‐[( m ‐; and  p ‐substituted)‐phenoxy]‐3a,4‐dihydro[1,2,4]oxadiazolo[4,5‐ a ][1,5]benzodiazepines | Zendy

Cortés Eduardo CortÉS | Zendy; Cruz Elide HernÁNdez | Zendy; Mellado Olivia GarcÍA | Zendy

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Synthesis and spectral properties of 5‐methylthio‐4 H ‐1‐( p ‐substituted‐phenyl)‐3a‐( p ‐substituted‐phenyl)‐9‐[( m ‐; and p ‐substituted)‐phenoxy]‐3a,4‐dihydro[1,2,4]oxadiazolo[4,5‐ a ][1,5]benzodiazepines

Author(s) -

Cortés Eduardo CortÉS,

Cruz Elide HernÁNdez,

Mellado Olivia GarcÍA

Publication year - 1999

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570360224

Subject(s) - chemistry , benzonitrile , triethylamine , cycloaddition , spectral properties , proton nmr , medicinal chemistry , nitrile , stereochemistry , benzodiazepine , chloride , carbon 13 nmr , organic chemistry , catalysis , computational chemistry , biochemistry , receptor

The preparation of eight novel substituted [1,2,4]oxadiazolo[4,5‐ a ][1,5]benzodiazepines which have potentially useful pharmacological properties; by 1,3‐cycloaddition of benzonitrile oxides, generated in situ from benzohydroxamoyl chloride and triethylamine, to 1,5‐benzodiazepine derivatives is described. The structure of all products was corroborated by ir, 1 H‐nmr, 13 C‐nmr and ms.

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