Synthesis and structure of novel 1,2‐dihydro‐phthalazine containing betaines | Zendy

Saczewski Franciszek | Zendy; Gdaniec Maria | Zendy

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Synthesis and structure of novel 1,2‐dihydro‐phthalazine containing betaines

Author(s) -

Saczewski Franciszek,

Gdaniec Maria

Publication year - 1998

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570350333

Subject(s) - chemistry , phthalazine , medicinal chemistry , stereochemistry

1,2‐Dihydro‐2‐(4,5‐dihydroimidazol‐2yl)phthalazin‐1‐ol 1 reacts exothermically with dialkyl acetylenedicarboxylates to give 3‐[2‐(4,5‐dihydro‐1 H ‐imidazol‐3‐iurn‐2‐yl)‐1,2‐dihydro‐1‐phthalazin]‐1,4‐dialkoxy‐1,4‐dioxo‐2‐buten‐2‐olates 7 and 8 . Enolic ester compounds underwent further transesterification reactions with formation of the betaines 9 and 10 . The unequivocal structural assignement of these compounds was achieved by spectroscopic 1 H and 13 C nmr methods as well as X‐ray analysis of 7 .

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