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Synthesis of novel indolizine derivatives
Author(s) -
Bonnaud Bernard,
Bigg Dennis,
Patoiseau JeanFrançois
Publication year - 1991
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570280820
Subject(s) - chemistry , indolizine , boron trifluoride , ethyl chloroformate , chloroformate , organic chemistry , catalysis
Abstract The reaction of a number of γ‐butyrolactones with azole anions is shown to give γ‐substituted butanoic acids in moderate to good yields. The pyrrolyl and indolylbutanoic acids obtained underwent cyclization in a simple one‐pot procedure employing ethyl chloroformate and boron trifluoride etherate. Some aspects of the chemistry of the resulting indolizin‐8‐ones are described.