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The synthesis of oxygen analogs of cepham. A new bicyclic system
Author(s) -
Sheehan John C.,
Dadiac Miroslav
Publication year - 1968
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570050607
Subject(s) - bicyclic molecule , chemistry , oxazines , oxygen , ring (chemistry) , chloride , lactam , combinatorial chemistry , stereochemistry , organic chemistry
Abstract The synthesis of a new bicyclic system has been reported. Three substituted 5,6‐dihydro‐1,3‐oxazines have been condensed to a fused β‐lactam ring system by use of phthaloylglycyl chloride. The resulting phthalimido compounds were dephthaloylated to the corresponding oxygen analogs of cepham (2).