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Microwave‐Assisted One‐Pot Synthesis of Substituted 3‐Bromoimidazo[1,2‐ a ]pyridines and Imidazoheterocycles
Author(s) -
Patil Shashikant M.,
Mascarenhas Malcolm,
Sharma Rajiv,
Mohana Roopan S.,
Roychowdhury Abhijit
Publication year - 2014
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1764
Subject(s) - chemistry , electrophile , halogenation , microwave , one pot synthesis , combinatorial chemistry , microwave irradiation , salt (chemistry) , organic chemistry , catalysis , physics , quantum mechanics
Herein, an efficient, one‐pot microwave‐assisted synthesis of a diverse set of 3‐bromoimidazo[1,2‐ a ]pyridines is being reported with good yields (40–85%). The method involves electrophilic aromatic bromination using bromodimethylsulfonium ion generated in situ via oxidation of HBr salt by DMSO. This methodology was also applied to the synthesis of related imidazoheterocycles. Copyright © 2014 HeteroCorporation