Open AccessLifestyle‐ and comorbidity‐related factors for the prescription of proton pump inhibitors after Helicobacter pylori eradication in Japan
Author(s) -
Shimada Furitsu,
Endo Hiroyoshi,
Takamori Ayako,
Matsunaga Takuya,
Fujimoto Shun,
Shirai Shimpei,
Kakiuchi Toshihiko,
Akutagawa Takashi,
Sakata Yasuhisa,
Node Koichi,
Yamanouchi Kohei,
Nakamura Shotaro,
Fujimoto Kazuma,
Esaki Motohiro
Publication year - 2021
Publication title -
jgh open
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.546
H-Index - 8
ISSN - 2397-9070
DOI - 10.1002/jgh3.12666
Subject(s) - medicine , medical prescription , helicobacter pylori , comorbidity , reflux esophagitis , esophagitis , proton pump inhibitor , gastroenterology , gastritis , gerd , risk factor , disease , reflux , pharmacology
Background and Aim The aim of the present study was to examine the lifestyle‐ and comorbidity‐related determinant factors of the prescription of proton pump inhibitors (PPIs) for patients in whom Helicobacter pylori has been eradicated, and to evaluate the relationship between PPI prescription and the severity of endoscopic esophagitis. Methods This retrospective study included patients who underwent H. pylori eradication from May 2012 to September 2016 at Saiseikai Karatsu Hospital. All patients received upper gastrointestinal endoscopy before H. pylori eradication. Patients with open peptic ulcers and/or malignant diseases were excluded, and a final total of 389 patients were evaluated. Medical records were reviewed to determine the prescription of PPIs after H. pylori eradication, lifestyle‐related factors, and comorbidities. Lifestyle‐related factors were confirmed by a questionnaire. Results PPIs were administered to 124 of 389 patients (31.9%). The only lifestyle‐related risk factor for the prescription of PPIs after H. pylori eradication was older age ( P < 0.01). Hypertension increased the prescription of PPIs ( P = 0.034). The prescription of PPIs was not influenced by the presence of grade A esophagitis, whereas the PPI prescription rate was significantly increased in patients with grades B/C/D endoscopic esophagitis ( P < 0.01). The grade of chronic gastritis before H. pylori eradication had no effect on the prescription of PPIs. Conclusion The lifestyle‐ and comorbidity‐related risk factors for the prescription of PPIs after H. pylori eradication were older age and hypertension, while mild endoscopic esophagitis had no influence on PPI prescription.