Open AccessFecal microbiota transplantation: Current status and challenges in China
Author(s) -
Shi YiChao,
Yang YunSheng
Publication year - 2018
Publication title -
jgh open
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.546
H-Index - 8
ISSN - 2397-9070
DOI - 10.1002/jgh3.12071
Subject(s) - medicine , pseudomembranous colitis , enema , medical prescription , traditional chinese medicine , china , transplantation , fecal bacteriotherapy , diarrhea , alternative medicine , pathology , antibiotics , clostridium difficile , nursing , microbiology and biotechnology , biology , law , political science
As early as the Western Zhou Dynasty of China in about 10th century BC, “Prescription Collection of Fifty-two Diseases” recorded the use of “golden juice” to treat infectious diseases. Afterward, in the “Prescription Collection of Emergency” edited by Dr. Ge Hong in the Eastern Jin Dynasty of China about 1700 years ago, FMT preparation called “yellow soup” was used to treat food poisoning and severe diarrhea. FMT appeared in English literature in 1958 when four patients with pseudomembranous colitis were treated with fecal enemas. In 1966, Luo et al. successfully treated two patients with pseudomembranous colitis using fecal enemas from Chinese healthy donors. In the last 5 years, FMT has gained popularity in China, mainly amongst Chinese gastroenterologists and pediatricians. At present, there are more than 10 Chinese tertiary hospitals conducting FMT clinical trials and related research in Beijing, Shanghai, Nanjing, Guangzhou, Xi’an, Tianjin, and Chongqing.