Open AccessIrreversible metronidazole encephalopathy in an elderly woman with primary biliary cholangitis
Author(s) -
Onuma Yuki,
Oki Masayuki,
Komatsu Masamichi,
Ishitani Sho,
Kijima Kei,
Fukuda Ryuki,
Moriya Yusuke,
Ozawa Hideki,
Takagi Atsushi
Publication year - 2017
Publication title -
journal of general and family medicine
Language(s) - English
Resource type - Journals
ISSN - 2189-7948
DOI - 10.1002/jgf2.91
Subject(s) - medicine , pathological , metronidazole , encephalopathy , hepatic encephalopathy , hepatic dysfunction , gastroenterology , symptomatic treatment , antibiotics , disease , cirrhosis , microbiology and biotechnology , biology
An 82‐year‐old woman with primary biliary cholangitis was diagnosed with an irreversible neurological disorder, caused by metronidazole ( MNZ )‐induced encephalopathy. Although the disorder is a reversible pathological condition, in rare cases, it can cause serious sequelae or could even be fatal. Therefore, medications should be administered carefully, particularly in patients who require long‐term administration of large doses or those with liver dysfunction.